Publications

2025

• ML Tan, Roy A, Plaster EM, Wolfenson H, Abraham A & Loebel C, Hydrogel Viscoelasticity Modulates Cell Nascent Extracellular Matrix Deposition. Macromolecular Rapid Communications 46, no. 21 (2025): e00435. https://doi.org/10.1002/marc.202500435
• Guo Y^, Ye J^, Odeh A, Trebicz-Geffen M, Wolfenson H* & Serge Ankri*. Enteropathogenic Escherichia coli induces Entamoeba histolytica Lévy-like movement on fibronectin-rich substrate by reducing traction forces. PLOS Pathogens 21(5): e1012618. doi.org/10.1371/journal.ppat.1012618. ^co-first author; *Co-corresponding author
• Wolfenson H, Giannone G & Schwartz MA; In Memoriam: Mike Sheetz. J Cell Biol 7 April 2025; 224 (4): e202503048. doi: https://doi.org/10.1083/jcb.202503048
• Layous M, Gildor T, Nehrera T, Qassema A, Wolfenson H & Ben-Tabou de-Leon S. A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo. PNAS, 2025 7;122(1):e2408628121. doi: 10.1073/pnas.2408628121

2024

• Hollander S^, Guo Y^, Wolfenson H* & Zaritsky A*. Spatiotemporal analysis of F-actin polymerization with micropillar arrays reveals synchronization between adhesion sites. Molecular Biology of the Cell, 2024. 35:br23. doi: 10.1091/mbc.E24-06-0276 ^co-first author; *co-corresponding author
• Jafarinia H, Lidan S, Wolfenson H & Carlier A. YAP phosphorylation within integrin adhesions: Insights from a computational model. Biophysical Journal, 2024. 123: 3658–3668. doi: 10.1016/j.bpj.2024.09.002
• Shi L, Nadjar-Boger E, Jafarinia H, Carlier A & Wolfenson H. YAP mediates apoptosis through failed integrin adhesion reinforcement. Cell Reports 43 (3). https://doi.org/10.1016/j.celrep.2024.113811

2023

• Honasoge K, Karagoz Z, Goult B, Wolfenson H, LaPointe VLS & Carlier A. Force-dependent focal adhesion assembly and disassembly: a computational study. PLOS Computational Biology, 19(10): e1011500. https://doi.org/10.1371/journal.pcbi.1011500
• Melamed S, Zaffryar-Eilot S, Nadjar-Boger E, Aviram R, Zhao H, Yaseen-Badarne W, Kalev-Altman R, Sela-Donenfeld D, Lewinson O, Astrof S, Hasson P* & Wolfenson H*. Initiation of fibronectin fibrillogenesis is an enzyme dependent process. Cell Reports, 2023. 42: 112473. doi: 10.1016/j.celrep.2023.112473 (*Co-corresponding Author).
• Bhattacharya A, Mukherjee A, Pisano S, Dimri S, Knaane E, Altshuler A, Nasser W, Dey S, Shi L, Mizrahi I, Jokel O, Amitai-Lange A, Kaganovsky A, Mimouni M, Socea S, Hasson P, Feral C, Wolfenson H* & Shalom-Feuerstein R*. Biomechanical property of limbal niche maintains stemness through YAP. Cell Death Differ 30, 1601–1614 (2023); doi: https://doi.org/10.1101/2021.05.25.445490 (*Co-corresponding Author).
• Moriel A, Wolfenson H & Bouchbinder E. 2023. Characteristic energy scales of active fluctuations in adherent cells. Biophysical Reports. 3: 100099. doi: https://doi.org/10.1016/j.bpr.2022.100099
• Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Wolf L, Wolfenson H* & Weil M. 2023. Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients. Front Cell Dev Biol. 11:1013721. doi: https://doi.org/10.3389/fcell.2023.1013721 (*Co-corresponding Author).

2022

• Qin R, Melamed S, Yang B, Saxena M, Sheetz MP & Wolfenson H. 2022. Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices. Front Cell Dev Biol. 10:959521. doi: https://doi.org/10.3389/fcell.2022.959521.
• Mukherjee A, Melamed S, Damouny-Khoury H, Amer M, Feld L, Nadjar-Boger E, Sheetz MP & Wolfenson H. α-Catenin links integrin adhesions to F-actin to regulate ECM mechanosensing and rigidity dependence. Journal of Cell Biology. 221(8): e202102121. doi: https://doi.org/10.1083/jcb.202102121

2021

• Amer M.; Shi L. & Wolfenson H. The ‘Yin and Yang’ of Cancer Cell Growth and Mechanosensing. Cancers 2021, 13, 4754.

2020

• Knany A, Engelman R, Hariri HA, Biswal S, Wolfenson H & Benhar M. 2020. S-nitrosocysteine and glutathione depletion synergize to induce cell death in human tumor cells: Insights into the redox and cytotoxic mechanisms. Free Radic. Biol. Med. 160:566–574. doi:10.1016/j.freeradbiomed.2020.08.026
• Shabi O, Natan S, Kolel A, Mukherjee A, Tchaicheeyan O, Wolfenson H, Kiryati N & Lesman A. 2020. Motion magnification analysis of microscopy videos of biological cells. PLoS One. 15:e0240127. doi:10.1371/journal.pone.0240127
• Shechter D, Harel M, Mukherjee A, Sagredo LM, Loven D, Prinz E, Avraham S, Orian-Rousseau V, Geiger T, Shaked Y & Wolfenson H. 2020. Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy. Cells. 9:2269. doi:10.3390/cells9102269
• Lazar I, Fabre B, Feng Y, Khateb A, Turko P, Martinez-Gomez MJ, Frederick DT, Levesque MP, Feld L, Zhang G, Zhang T, James B, Shklover J, Avitan Hersh E, Livneh I, Scortegagna M, Brown K, Larsson O, Topisirovic I, Wolfenson H, Herlyn M, Flaherty K, Dummer R & Ronai ZA. 2020. SPANX control of Lamin A/C modulates nuclear architecture and promotes melanoma growth. Mol. Cancer Res. molcanres.0291.2020. doi:10.1158/1541-7786.MCR-20-0291
• Feld L, Kellerman L, Mukherjee A, Livne A, Bouchbinder E & Wolfenson H. 2020. Cellular contractile forces are nonmechanosensitive. Sci. Adv. 6:eaaz6997. doi:10.1126/sciadv.aaz6997

2019

• Yang B, Wolfenson H, Chung VY, Nakazawa N, Liu S, Hu J, Huang RY & Sheetz MP. Stopping transformed cancer cell growth by rigidity sensing. Nat. Mater. (2019). doi:10.1038/s41563-019-0507-0
• Wolfenson H, Yang B & Sheetz MP. Steps in Mechanotransduction Pathways that Control Cell Morphology. Annu Rev Physiol, 2019. 81: p. 585-605

2017

• Saxena M, Changede R, Hone JC, Wolfenson H*, Sheetz MP*. Force induced calpain cleavage of talin is critical for growth, adhesion development and rigidity sensing. Nano Letters (Published online October 2017, doi: 10.1021/acs.nanolett.7b02476). (*Co-corresponding author).
• Saxena M, Liu S, Bo Y, Hajal C, Changede R, Hu J, Wolfenson H*, Hone J*, Sheetz MP*. EGFR and HER2 activate rigidity sensing only on rigid matrices. Nature Materials (Published online May 2017, doi:10.1038/nmat4893 (2017). (*Co-corresponding author).

Before 2017

• Yang B, Lieu ZZ, Wolfenson H, Hameed FM, Bershadsky AD & Sheetz MP. Mechanosensing Controlled Directly by Tyrosine Kinases. Nano Lett 16, 5951-5961, doi:10.1021/acs.nanolett.6b02995 (2016).
• Meacci G*, Wolfenson H*, Stachowiak MR, Iskratsch T, Liu S, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Gondarenko A, Chander AC, O’Shaughnessy B, Hone J & Sheetz MP (2016). Alpha‐actinin links rigidity‐sensing contractile units with periodic cell edge retractions. Mol Biol Cell, doi:10.1091/mbc.E16-02-0107 (2016). (*Equal Contribution)
• Cai H, Wolfenson H, Depoil D, Dustin ML, Sheetz MP & Wind SJ (2016). Molecular occupancy of nanodot arrays. ACS Nano 10, 4173‐4183.
• Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca‐Cusachs P, O’Shaughnessy B, Hone J & Sheetz MP (2016). Tropomyosin controls sarcomere‐like contractions for rigidity sensing and suppressing growth on soft matrices. Nat Cell Biol 18, 33‐42.
  4 recommendations on the F1000Prime website.
• Wolfenson H, Iskratsch T & Sheetz MP (2014). Early events in cell spreading as a model for quantitative analysis of biomechanical events. Biophys J 107, 2508‐2514.
• Iskratsch T*, Wolfenson H* & Sheetz MP (2014). Appreciating force and shape‐the rise of mechanotransduction in cell biology. Nat Rev Mol Cell Biol 15, 825‐833. (*Equal Contribution).
• Lavelin I, Wolfenson H, Patla I, Henis YI, Medalia O, Volberg T, Livne A, Kam Z, Geiger B (2013). Differential effect of actomyosin relaxation on the dynamic properties of focal adhesion proteins. PLoS ONE 8, e73549.
• Wolfenson H, Lavelin I, Geiger B. (2013). Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell 24, 447‐458.
• Berkovich R*, Wolfenson H*, Eisenberg S, Ehrlich M, Weiss M, Klafter J, Henis YI, Urbakh M (2011). Accurate Quantification of Diffusion and Binding Kinetics of Non‐integral Membrane Proteins by FRAP. Traffic 12, 1648‐1657. (*Equal Contribution).
• Wolfenson H, Bershadsky AD, Henis YI, Geiger B (2011). Actomyosin‐generated tension controls the molecular kinetics of focal adhesions. J Cell Sci 124, 1425‐1432. The most‐read research paper in J Cell Sci in 2011
• Wolfenson H, Henis YI, Geiger B, Bershadsky AD (2009). The heel and the toe of the cell’s foot: a multifaceted approach for understanding structure and dynamics of focal adhesions. Cell Motil Cytoskeleton 66, 1017‐1029.
• Wolfenson H, Lubelski A, Regev T, Klafter J, Henis YI, Geiger B (2009). A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS ONE 4, e4304.
• Gilead S, Wolfenson H, Gazit E (2006). Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin. Angew Chem Int Ed Engl  45, 6476‐6480.